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Severe toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and eldepryl selegiline hcl and selective serotonin reuptake inhibitors and eldepryl.

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After you have been taking selegiline for 2 or 3 days.your doctor may direct you to lower your levodopa dose. Follow your doctor’s instructions closely. Do not stop or order eldepryl cost the dose of any of your medications without first talking with your doctor.

The decision to prescribe selegiline should take into consideration that the MAO system of enzymes is complex and incompletely understood and there is only a limited amount of carefully documented clinical experience with selegiline. Consequently.the full spectrum of possible responses to selegiline may not have been observed in pre-marketing evaluation of the drug. It is advisable.therefore.to observe patients closely for atypical responses.

If you are taking the orally disintegrating tablet.your doctor may start you on a low dose of selegiline and increase your dose after order eldepryl cost weeks.

Because selegiline’s inhibition of MAO-B is irreversible.it is impossible to predict the extent of MAO-B inhibition from steady state plasma levels. For the same reason.it is not possible to predict the rate of recovery of MAO-B activity as a function of plasma levels. The recovery of MAO-B activity is a function of de novo protein synthesis. however.information about the rate of de novo protein synthesis is not order eldepryl cost available. Although platelet MAO-B activity returns to the normal range within 5 to 7 days of selegiline discontinuation.the linkage between platelet and brain MAO-B inhibition is not fully understood nor is the relationship of MAO-B inhibition to the clinical effect order eldepryl cost (see CLINICAL PHARMACOLOGY ).

No pharmacokinetic information is available on selegiline or its metabolites in hepatically impaired subjects.

Get emergency medical help if you have signs of an allergic reaction to Eldepryl . hives. difficult breathing. swelling of your face.lips.tongue.or throat.

The concomitant administration of the selective MAO-B inhibitor selegiline and pethidine and other opioids is contraindicated.

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do not take this medicine with any of the following medications -certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole -cisapride -dofetilide -dronedarone -linezolid -maois like carbex, eldepryl, marplan, nardil, and parnate -mesoridazine -methylene blue injected into a vein -pimozide -saquinavir -thioridazine -ziprasidone this medicine may also interact with the following medications -alcohol -antiviral medicines for hiv or aids -aspirin and aspirin-like medicines -barbiturates like phenobarbital -certain medicines for blood pressure, heart disease, irregular heart beat -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan -certain medicines for seizures like carbamazepine and phenytoin -certain medicines for sleep -certain medicines that treat or prevent blood clots like dalteparin, enoxaparin, warfarin -digoxin -fentanyl -lithium -nsaids, medicines for pain and inflammation, like ibuprofen or naproxen -other medicines that prolong the qt interval cause an abnormal heart rhythm -rasagiline -supplements like st.

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