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Current theories on the aetiology of migraine headache suggest that the symptoms are due to local cranial vasodilatation and/or to the release of vasoactive and pro-inflammatory peptides from sensory nerve endings in an activated trigeminal system. The therapeutic activity of rizatriptan in migraine can most likely be attributed to agonist effects at 5-HT 1B/1D receptors on the extracerebral.intracranial blood vessels.which become dilated during a migraine attack.and on nerve terminals in the trigeminal system. Activation of these receptors results in cranial vessel constriction.inhibition of neuropeptide release and reduced transmission in trigeminal pain pathways.
If you experience migraine attacks less frequently.these medicines may give you quick relief.
Rizatriptanshould not be given to patients with ischemic or vasospastic coronary artery disease. There have been rare reports of serious cardiac adverse reactions.including acute myocardial infarction.occurring within a few hours following administration of rizatriptan . Some of these reactions occurred in patients without known coronary artery disease (CAD). 5-HT1 agonists.including rizatriptanmay cause coronary artery vasospasm (Prinzmetal’s Angina).even in patients without a history of CAD.
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