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However.if it’s almost time for your next dose.skip the missed dose and continue on your regular dosing schedule.

The adverse experiences observed in patients in uncontrolled studies were similar to those seen in controlled clinical studies.

Extended-release capsules (Rytary). Swallow whole. Do not chew.divide or crush the capsules. May give with or without food. A high-fat.high-calorie meal may delay the absorption of levodopa by about 2 hours. For patients who have difficulty swallowing intact capsules. May administer by carefully twisting apart both halves of the capsule.sprinkling the entire contents of both halves on a small amount of applesauce (1 to 2 tablespoons). Have the patient consume immediately. Do not store the drug/food mixture for future administration.

Dopamine Dysregulation Syndrome (DDS) is an addictive disorder seen in some patients treated with carbidopa/ levodopa. Affected patients show a compulsive pattern of dopaminergic drug misuse above doses adequate to control motor symptoms.which may in some cases result in severe dyskinesias (see also section 4.4).

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